More celebrities than ever have confirmed using Ozempic and Mounjaro for weight management in 2026. Here is the definitive list of who has spoken publicly about their GLP-1 journey.

Oprah Winfrey confirmed Mounjaro use in late 2023, calling it "that wonderful shot." She hosted a prime-time special on weight-loss stigma and stepped down from the Weight Watchers board.

The Australian actress confirmed she tried Ozempic during her Year of Health in 2020. She combined medication with grueling two-hour daily workouts and a high-protein eating plan.

Amy Schumer openly posted about Mounjaro on Instagram, while Meghan Trainor confirmed using Mounjaro for postpartum weight management. Both earned praise for their honesty.

Ozempic (semaglutide) targets GLP-1 receptors, while Mounjaro (tirzepatide) hits both GLP-1 and GIP. Clinical trials show Mounjaro may deliver up to 22% body-weight loss.