The Boys season 5 cast and characters guide starts with Amazon's farewell roster: Karl Urban leads the Boys in eight final episodes alongside Jack Quaid, Erin Moriarty, and Karen Fukuhara.

Urban returns as Billy Butcher wielding a Supe-killing virus for one last assault on Homelander. Kripke told The Hollywood Reporter Butcher killing Homelander was planned from the series' earliest development weeks.

Jack Quaid returns as Hughie Campbell, the conscience opposite Butcher; Erin Moriarty's Starlight leaks Flight 37 footage and fights Homelander's theocracy. The finale sets them up for parenthood.

Antony Starr closes the franchise as Homelander chasing V1 immortality. Susan Heyward's Sage, Valorie Curry's Firecracker, and Daveed Diggs' Oh Father expand Vought's authoritarian bench.

Jensen Ackles returns as Soldier Boy; Jared Padalecki plays Mister Marathon and Misha Collins plays Malchemical in Kripke's Supernatural reunion. Mason Dye guest stars as Bombsight.