Only Murders in the Building season 5 cast guide opens with Martin, Short, Gomez, and Creighton as main cast — plus Streep, Zellweger, Waltz, Cannavale, Key, and nine headline newcomers per Hulu.

Martin as Charles, Short as Oliver, and Gomez as Mabel lead all ten episodes investigating doorman Lester Coluca death mystery. Entertainment Weekly confirmed the trio anchors every hour of Season 5.

Teddy Coluca plays deceased doorman Lester; Wiest is widow Lorraine; Fowler is protégé Randall Winston. Their arcs drive the season-long finger-and-casino mystery per episode credits.

Randolph returns as Detective Donna Williams; Creighton continues neighbor Howard Morris in seven episodes. Both assist and complicate the unofficial Arconia investigation throughout the season.

Cannavale is mobster Nicky; Leoni is wife Sofia. Waltz, Zellweger, and Lerman play billionaire poker rivals Bash, Camila, and Jay Pflug — announced March through August 2025.