Ozempic and Mounjaro have taken Hollywood by storm. Both are GLP-1 medications, but they work differently. Here is what celebrities on Ozempic and Mounjaro need you to know.

Ozempic contains semaglutide, which mimics the GLP-1 hormone. It reduces appetite, slows digestion, and helps regulate blood sugar. Average weight loss in trials reached 15-17% of body weight.

Mounjaro uses tirzepatide, targeting both GLP-1 and GIP receptors. This dual action produced average weight loss of 22.5% in clinical trials — the highest of any approved obesity medication.

Nausea, vomiting, and diarrhea are common during dose increases. Amy Schumer stopped Mounjaro due to severe nausea. Others report "Ozempic face" from rapid facial volume loss.

Without insurance, both drugs cost $900 to $1,300 per month. Demand has improved insurance coverage, but shortages still affect diabetic patients who rely on these medications.